Biochemical Society Symposia Volume 61

Free Radicals and Oxidative Stress: Environment, Drugs and Food Additives

Edited by C. Rice-Evans, B. Halliwell and G.G. Lunt

Preface..........vii

Abbreviations..........xi

1 Oxidative stress: the paradox of aerobic life

K.A.J. Davies..........1–31

2 Nitric oxide and reactive oxygen species in vascular injury

H. Rubbo, M. Tarpey and B.A. Freeman..........33–45

3 Ultraviolet radiation and free radical damage to skin

R.M. Tyrell..........47–53

4 Thiyl radicals in biological systems: significant or trivial?

B. Kalyanaraman..........55–63

5 The chemistry of lipid alkoxyl radicals and their role in metal-amplified lipid peroxidation

L.J. Marnett and A.L. Wilcox..........65–72

6 How to characterize an antioxidant: an update

B. Halliwell..........73–101

7 Plant polyphenols: free radical scavengers or chain-breaking antioxidants?

C. Rice-Evans..........103–116

8 Plant carotenoids and related molecules: important dietary antioxidants

N.I. Krinsky..........117–126

9 Therapeutic iron chelators and their potential side effects

S. Singh, H. Khoddr, M.I. Taylor and R.C. Hider..........127–137

10 Oxidative damage by ozone and nitrogen dioxide: synergistic toxicity in vivo but no evidence of synergistic oxidative damage in extracellular fluid

C.A. O’Neill, A. van der Vliet, J.P. Eiserich, B. Halliwell, J.A. Last and C.E. Cross..........139–152

11 Biological and biochemical effects of air pollutants: synergistic effects of sulphite

S. Hippeli and E.F. Elstner..........153–161

12 Myeloperoxidase as a generator of drug free radicals

J.P. Uetrecht..........163–170

13 Radicals from one-electron reduction of nitro compounds, aromatic N-oxides and quinones; the kinetic basis for hypoxia-selective bioreductive drugs

P. Wardman, M.F. Dennis, S.A. Everett, K.B. Patel, M.R.L. Stratford and M. Tracy..........171–194

14 Side-effects of drugs used in the treatment of rheumatoid arthritis

P.J. Evans and B. Halliwell..........195–207

15 Tamoxifen as an antioxidant and cardioprotectant

H. Wiseman..........209–219

16 Antioxidant agents in raw materials and processed foods

C.E. Eriksson and A. Na..........221–234

17 Antioxidants in food packaging: a risk factor?

G. Scott..........235–246

18 Free radicals and food irradiation

N.J.F. Dodd..........247–258

19 Atherogenic and anti-atherogenic factors in the human diet

P.B. Addis, T.P. Carr, C.A. Hassel, Z.Z. Huang and G. J. Warner..........259–271

Subject index..........273